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目的 探讨食管小细胞癌的外科治疗和综合治疗的方法和疗效。方法 回顾分析我科1981~2004年外科治疗的食管小细胞癌19例的临床特征、治疗方法并进行随访,与同期收治广泛期未手术2例进行比较,分析治疗方法与预后的关系。结果19例行外科治疗,术后辅助化疗和放疗,1、3、5年生存率分别为56.25%(9/16)、27.27%(3/11)、10%(1/10),术后生存时间4~68个月,中位生存时间16个月。同期收治2例广泛期行单纯化疗,生存时间分别为2个月和7 个月。外科治疗明显优于非手术者。结论 食管小细胞癌恶性程度高,转移早,预后差,外科手术加上全身化疗和(或)放疗可明显提高食管小细胞癌生存时间。
Objective To investigate the surgical treatment and comprehensive treatment of esophageal small cell carcinoma and its efficacy. Methods The clinical features, treatment and follow-up of 19 patients with surgical treatment of esophageal small cell carcinoma in our department from 1981 to 2004 were retrospectively analyzed. The relationship between the treatment and prognosis was analyzed comparing with the two cases without extensive surgery in the same period. Results Survival rate of 1, 3 and 5 years after surgery was 19.25% (9/16), 27.27% (3/11) and 10% (1/10) respectively after 19 cases were treated with adjuvant chemotherapy and radiotherapy. After operation Survival time of 4 to 68 months, the median survival time of 16 months. The same period, 2 cases were treated extensively with simple chemotherapy, survival time was 2 months and 7 months. Surgical treatment was significantly better than non-operation. Conclusion Small cell carcinoma of the esophagus has high malignant degree, early metastasis and poor prognosis. Surgical operation combined with systemic chemotherapy and / or radiotherapy can significantly improve the survival time of small cell carcinoma of the esophagus.