用~(125)Ⅰ-心钠素放射自显影和受体分析法证明,在大鼠肾脏、血管壁和人的血管床上有心钠素的特异结合部位。这种结合可以特异地被人工合成的心钠素所竞争、取代,而不能被其他的肽所竞争、取代。放射自显影显示,这些特异结合部位主要分布在肾小球、肾脏皮、髓质交界处肾小管的上皮细胞和血管壁的平滑肌细胞。 Radioimmunoimaging with ~ (125) I-atrial natriuretic peptide and receptor analysis demonstrated that there are specific binding sites for atrial natriuretic peptide in rat kidney, vascular wall and human vascular beds. This combination can be specifically synthesized by atrial natriuretic peptide competition, substitution, and can not be competed by other peptides, replaced. Autoradiography showed that these specific binding sites were mainly located in the epithelial cells of the renal tubules and the smooth muscle cells of the vascular wall in the glomerular, renal dermis and medulla junction.