论文部分内容阅读
作者对16例胃溃疡病人和35例十二指肠病人作双盲试验法,在门诊给予丙谷酰胺(Proglumide,即 N-苯酰-N’,N’-二正丙基-dl-异谷酰胺)每天1,200mg,或三矽酸镁每天1,320mg,共4周。治疗前后作内窥镜检查,观察其溃疡的变化。结果丙谷酰胺治疗的8例胃溃疡病人(男5,女3,平均年龄48.6岁)有6例(75%)溃疡愈合;三矽酸镁治疗的8例胃溃疡病人(男6,女2,平均年龄46.5岁)只有2例(25%)溃疡愈合,两者疗效有显著差别(P<0.05)。丙谷酰胺治疗的17例十二指肠溃疡病人(男14,女3,平均年龄49岁)有10例(59%)溃疡愈合;三矽酸镁治疗的18例(男14,女4,平均年龄57岁)有11例(61%)溃疡愈合;两者无显著差别。丙谷酰胺对基础的或最大刺激酸分泌没有影响,对血清胃泌素值的变化
The authors conducted a double-blind trial of 16 patients with gastric ulcer and 35 patients with duodenal disease. Proglumide (N-benzoyl-N ’, N’-di-n-propyl-dl- Glutamine) 1,200 mg daily, or 1,320 mg daily for three weeks. Before and after treatment for endoscopic examination to observe the changes of ulcers. Results Eight of eight patients with gastric ulcer treated with valproamide (6 males and 3 females, with an average age of 48.6 years) had ulceration healing in 6 patients (75%). Eight patients with gastric ulcer (male 6 and female 2) , Average age 46.5 years old) only 2 cases (25%) ulcer healed, the curative effect of both has significant difference (P <0.05). Ten cases (59%) of the ulcer healed in 17 patients with duodenal ulcer treated with valproate (male 14, female 3, mean age 49 years); 18 (male 14, female 4, The mean age was 57 years old), ulcers healed in 11 cases (61%); there was no significant difference between the two groups. Proglutamines have no effect on basal or maximal stimulatory acid secretion, changes in serum gastrin values