论文部分内容阅读
目的 :评价抗精子抗体 (anti -spermantibody ,AsAb)与反复自然流产 (recurrentspontaneousabortion ,RSA)小鼠模型CBA/J×DBA/ 2生殖力特点的关系 .方法 :对CBA/J×DBA/ 2小鼠的生殖力特点做为期 6 0d的观察 ,与生殖力正常的BALB/c×DBA/ 2小鼠进行比较 ,并检测上述雌鼠血清AsAb水平 .结果 :CBA/J×DBA/ 2小鼠平均每窝产仔数和雌雄同笼至第 1窝鼠仔出生的平均时间均与BALB/c×DBA/ 2小鼠有显著差异 ,分别为 (3 0± 1 1)只与 (6 1± 1 6 )只 ,P <0 0 0 1,和 (33 5± 7 1)d与 (2 5 8± 3 2 )d ,P <0 0 1.在这些CBA/J×DBA/ 2和BALB/c×DBA/ 2组合的雌鼠血清中均未检测出AsAb .结论 :CBA/J×DBA/ 2小鼠生殖力的下降可能并非由于雌鼠血清中存在AsAb所致
Objective: To evaluate the relationship between anti-spermantibody (AsAb) and CBA / J × DBA / 2 reproductive performance in a mouse model of recurrent spontaneous abortion (RSA) .Methods: CBA / J × DBA / 2 mice Of the fecundity characteristics of 60 days of observation, with fertility normal BALB / c × DBA / 2 mice were compared and serum levels of AsAb were detected.Results: CBA / J × DBA / 2 mice on average The mean litter size of litter size and litter size to the first litter size was significantly different from that of BALB / c × DBA / 2 mice (3 0 ± 1 1) and (6 1 ± 1 6 ) Alone, P <0 0 01, and (33 5 ± 7 1) d and (2 58 ± 3 2) d, P 0 01. In these CBA / J × DBA / 2 and BALB / c × AsAb was not detected in serum of DBA / 2 combination female mice Conclusions: The decline of fecundity in CBA / J × DBA / 2 mice may not be caused by AsAb