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目的研究血清PSA水平与前列腺癌病理组织学类型的关系,以提高前列腺癌的早期诊断水平。方法选择经手术证实的前列腺癌(PCa)组50例和前列腺增生(BPH)组50例,术前均测定血清TPSA、FPSA和P(V)、RI水平并与病理组织学类型进行比较相关分析,采用SPSS 10．0统计学处理。结果PCa组与BPH组比较,血清中TPSA,FPSA,F/T比值,PSAD和P(V)水平两组差异有显著性意义(P<0．01)。低分化癌组与高分化癌相比较:血清TPSA、FPSA、PSAD和RI水平两组差异有显著性差异(P<0．05)。比较分析表明血清TPSA、FPSA、PSAD和RI水平与前列腺癌病理组织学类型密切相关(r≈0．4),而F/T比值和P(V)无相关性。结论PSA是前列腺早期诊断和预后判断的可靠指标。
Objective To study the relationship between the level of serum PSA and the histopathological type of prostate cancer in order to improve the early diagnosis of prostate cancer. Methods Fifty cases of prostate cancer (PCa) group and 50 cases of benign prostatic hyperplasia (BPH) group were selected. The levels of serum TPSA, FPSA, P (V) and RI were measured before operation and compared with histopathological types , Using SPSS 10.0 statistical analysis. Results Compared with BPH group, the levels of TPSA, FPSA, F / T, PSAD and P (V) in serum of PCa group were significantly different (P <0.01). Compared with well-differentiated carcinoma, the difference of serum TPSA, FPSA, PSAD and RI between the two groups was significant (P <0.05). Comparative analysis showed that serum TPSA, FPSA, PSAD and RI levels were closely related to histopathological types of prostate cancer (r ≈ 0.4), while there was no correlation between F / T ratio and P (V). Conclusions PSA is a reliable indicator of early diagnosis and prognosis of prostate.