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GCLE(7-phenylacetamide-3-chloromethyl-3-cepham-4-carboxylic acid p-methoxybenzyl ester) as an important intermediate of cephalosporin antibiotics is not new in China. GCLE,7-ADCA (7-aminodeacetoxyl) and 7-ACA (7-aminocephalosporanic acid) are called three major cephalosporin antibiotic intermediates.