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A model peptide,TDK,was studied by circular dichroism to elucidate the effect of organic solvent on α-helical formation.The α-helicities enhanced by various alcohol solvents,especially fluorine-substituted alcohols were systematically compared.The relations between α-helical formation of a peptide and external environment were also discussed in detail.These environmental elements mainly include hydrophobicity dielectric constant and acidity of the solvents.
A model peptide, TDK, was studied by circular dichroism to elucidate the effect of organic solvent on α-helical formation. Α-helicoids enhanced by various alcohol solvents, especially fluorine-substituted alcohols were systematically compared. The relations between α-helical formation of a peptide and external environment were also discussed in detail. The environmental elements mainly include hydrophobicity dielectric constant and acidity of the solvents.