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以聚乙二醇99-b-聚丙二醇69-b-聚乙二醇99(PEO99-b-PPO69-b-PEO99 Pluronic F127)为大分子引发剂,引发己内酯(CL)和6-乙酸苄酯-己内酯(BCL)开环聚合得到一系列不同BCL含量的两亲性嵌段共聚物Pluronic-b-poly((ε-caprolactone)-co-(6-(benzyl-oxycarbonylmethyl)-ε-caprolactone))(Pluronic-b-P(CL-co-BCL)).通过核磁共振,红外光谱和凝胶渗透色谱确定共聚物的结构、组成和分子量及其分布.热重分析、X射线衍射和差示扫描量热法的结果表明,聚合物的热稳定性及结晶性均可通过调控共聚物中BCL的含量进行调控.通过乳化溶媒挥发法制备聚合物胶束,并用荧光光谱,扫描电镜和粒径分析仪研究聚合物胶束的形成,形态和大小,结果表明胶束呈现规整球形且分布较为均匀,均具有较小的临界胶束浓度且受聚合物中BCL比例的影响;由光散射的结果看出,随着BCL的引入,Pluronic-b-P(CL-co-BCL)胶束粒径呈现出可逆的温度敏感性变化.
Polyethylene glycol 99-b-polypropylene glycol 69-b-polyethylene glycol 99 (PEO99-b-PPO69-b-PEO99 Pluronic F127) was used as a macroinitiator to induce caprolactone (CL) and 6- A series of amphiphilic block copolymers with different BCL content were obtained by ring-opening polymerization of benzyl ester-caprolactone (BCL). Pluronic-b-poly (ε-caprolactone) -co- -caprolactone) (Pluronic-bP (CL-co-BCL)) The structure, composition and molecular weight of the copolymer and its distribution were confirmed by NMR, IR and gel permeation chromatography.TRothermogravimetric analysis, X-ray diffraction and differential The results of scanning calorimetry show that the thermal stability and crystallinity of the polymer can be regulated by controlling the content of BCL in the copolymer.The polymer micelles were prepared by emulsification solvent evaporation method and characterized by fluorescence spectroscopy, scanning electron microscopy The diameter analyzer was used to study the formation, morphology and size of the polymer micelles. The results showed that the micelles were regularly spherical and uniformly distributed, both had small critical micelle concentration and were affected by the ratio of BCL in the polymer. The results showed that with the introduction of BCL, Pluronic-bP (CL-co-BCL) micelles showed a reversible temperature-sensitive particle size Variety.