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探讨血清可溶性白细胞介素-2受体(sIL-2R)水平对小儿结核病的临床应用价值。报告86例小儿血清sIL-2R的检测结果,其中对照组30例血清sIL-2R水平为(151.67±37.70)mmol/L,结核病活动期组32例血清sIL-2R水平为(289.38±86.62)mmol/L,两者有显著性差异(P<0.01)。经抗痨治疗半年～1年后(即结核病恢复期组),血清sIL-2R水平明显下降至(139.58±49.36)mmol/L,与活动组比较具显著性差异(P<0.01),接近健康对照组水平(P>0.05)。血清sIL-2R水平亦能反映结核病活动期病变的严重程度,重度结核病活动期组sIL-2R水平明显高于轻、中度结核病活动期组(均P<0.01)。sIL-2R检测是结核病诊断的敏感指标之一,可作为判定结核病患儿病情活动的客观指标,并有助判断抗痨治疗的效果。
To investigate the clinical value of serum soluble interleukin-2 receptor (sIL-2R) in children with tuberculosis. Serum levels of sIL-2R in the control group (151.67 ± 37.70) mmol / L and serum sIL-2R level in the active stage group (289.38 ± 86.62) mmol / / L, there was a significant difference (P <0.01). Serum levels of sIL-2R decreased significantly to (139.58 ± 49.36) mmol / L after anti-tuberculosis treatment for six months to one year (ie, tuberculosis recovery group), which was significantly different from that in the active group (P <0.01) Control group level (P> 0.05). The level of serum sIL-2R also reflects the severity of active stage of tuberculosis. The level of sIL-2R in active stage of severe tuberculosis was significantly higher than that in active stage of mild and moderate tuberculosis (all P <0.01). sIL-2R detection is one of the sensitive indicators of tuberculosis diagnosis, which can be used as an objective index to judge the disease activity in children with tuberculosis and help to judge the effect of anti-tuberculosis treatment.