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本文报道用血中DNA含量、抗DNA抗体及血清蛋白总量及其组成作指标,研究了慢性红斑狼疮病人的免疫状态。全部病人LE细胞均为阴性。 20名病人测定了血DNA浓度,其正常值为0.03～0.15微克/10,000白细胞(单位下同)。5名盘状型正常或轻度升高(0.13～0.21),其余15名明显升高,其中有2名盘状型为0.25、0.26,有12名播散型,皮损泛发、有明显的红斑及浸润,其DNA高达0.28～0.92。数据表明,血DNA含量与皮损广泛度有明显关系。为揭示抗核因子,作者按Oakly等法用琼脂沉淀反应(APR)测定抗DNA抗体及按Van So-
This article reports the use of blood DNA content, anti-DNA antibodies and serum proteins and their composition as an index to study the immune status of patients with chronic lupus erythematosus. All patients with LE cells were negative. Twenty patients measured blood DNA concentrations, which ranged from 0.03 to 0.15 μg / 10,000 leukocytes (same units). Five patients with normal or mild disc type (0.13 ~ 0.21), and the remaining 15 were significantly increased, of which two disc-shaped 0.25, 0.26, there are 12 disseminated lesions were common, with obvious Of erythema and infiltration, the DNA up to 0.28 ~ 0.92. The data show that there is a clear relationship between blood DNA content and the extent of lesions. To reveal the anti-nuclear factor, the authors used Oakley et al. To determine anti-DNA antibodies by agarose precipitation (APR) and by Van So-