应激性溃疡消化道大出血是颅脑损伤严重并发症之一,以往常使用H_2-受体阻断剂治疗,效果不佳。我科于2000年10月～2002年4月应用新药人工合成的环状十四肽生长抑素的类似物施他宁联合凝血酶治疗重型颅脑损伤并发应激性溃疡大出血40例,疗效满意,现报道如下。 1 资料与方法 Stress ulcer gastrointestinal bleeding is a serious complication of craniocerebral injury, the previous use of H_2-receptor blockers, the effect is not good. Our department in October 2000 ~ April 2002 application of synthetic new drugs synthetic cyclic tetrapeptide somatostatin analogues Shi Ning with thrombin in the treatment of severe craniocerebral injury complicated with stress ulcer bleeding in 40 cases, the effect is satisfactory Now reported as follows. 1 data and methods