目的：研究血吸虫病患者 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平及其临床意义。方法：用 Ｒ Ｔ Ｐ Ｃ Ｒ 加 ｄｏｔｂｌｏｔ法测定血吸虫病患者 Ｐ Ｂ Ｍ Ｃ中 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平，与肝硬变和肝癌患者作比较，并研究了部分肝脏组织（肝癌患者１６ 例，肝血管瘤患者正常肝组织 ５ 例）中 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平与 Ｐ Ｂ Ｍ Ｃ中水平的关系。同时，测定血清中 Ｈ Ａ、 Ｌ Ｎ、 ＣｏｌⅠⅤ和 Ｐ ＣⅢ水平，作为衡量肝纤维化活动与否的指标。结果： Ｐ Ｂ Ｍ Ｃ内 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平在晚期血吸虫病患者组（ｎ＝ ２１，１２６±０１４），肝硬变患者组（ｎ＝ １５，２０５±０８１）和肝癌患者组（ｎ＝ ２５，１８３±１２９）均显著高于正常对照组（ｎ＝ １６，０６２±０４０）（ Ｐ＜ ００５）。其中晚期血吸虫病患者组又显著低于肝硬变患者组或肝癌患者组（ Ｐ＜ ００５），后两组差异无显著性（ Ｐ＞ ００５）。肝组织与 Ｐ Ｂ Ｍ Ｃ内 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平差别无统计学意义（ Ｐ＞ ００５）。血清 Ｈ Ａ、 ＣｏｌⅣ和 Ｌ Ｎ 异常组的 Ｔ Ｇ Ｆβ１ ｍ Ｒ Ｎ Ａ 水平显著高于正常组（ Ｐ＜ ００５）。结论： Ｐ Objective: To study the level of T G F β 1 m R N A in patients with schistosomiasis and its clinical significance. Methods: RT-PCR and Dotblot were used to determine the level of T G F -β1 m R N A in patients with schistosomiasis, compared with patients with cirrhosis and hepatocellular carcinoma. Some liver tissues (hepatocellular carcinoma 16 cases of patients, liver hemangiomas in patients with normal liver tissue in 5 cases) T G F β1 m R N A level and the relationship between the level of PBMC. At the same time, serum H A, L N, Col  Ⅰ V and P C Ⅲ levels were measured as a measure of liver fibrosis activity or not. Results: The level of T G F -β1 m R N A in PBMC was significantly higher in patients with advanced schistosomiasis (n = 21,126 ± 014), patients with cirrhosis (n = 15,205 ± 081) and liver cancer patients (n = 25,183 ± 129) were significantly higher than the normal control group (n = 16,0  62 ± 040) (P <0  05). Among them, the group of patients with advanced schistosomiasis was significantly lower than those with cirrhosis or hepatocellular carcinoma (P <005). There was no significant difference between the two groups (P> 0.05). There was no significant difference in T G F  β1 m R N A level between liver tissues and PBMCs (P> 005). The levels of T G F -β1 m R N A in serum H A, Col Ⅳ and L N abnormalities group were significantly higher than those in normal group (P <005). Conclusion: P