恶性肉芽肿又称坏死性肉芽肿,是一种进行性肉芽增殖性溃疡性病变。多始发于鼻部及面部组织,以后逐渐侵犯多处内脏器官,予后不良,死亡率高达。80—90%。Friedmann(1964)提出将发生于面部中线,不伴有全身改变者称为Stewart型(肿瘤型);伴发上、下呼吸道坏死性肉芽肿,全身播散性坏死性血管炎及灶性坏死性 Malignant granuloma, also known as necrotizing granuloma, is a progressive granulomatous ulcerative disease. Mostly originated in the nose and facial tissues, and later gradually infringed a number of internal organs, post-bad, up to mortality. 80-90%. Friedmann (1964) proposed that it would occur in the midline of the face and was referred to as the Stewart type (tumor type) without systemic changes; with necrotizing granulomas of the upper and lower respiratory tract, disseminated necrotizing vasculitis and focal necrosis