细胞和组织的DNA损伤修复是影响细胞存活和死亡的主要原因。目前认为 ,DNA损伤与修复在缺血神经细胞死亡机制中发挥重要的作用。本文主要阐述了DNA损伤修复的分子机制、与细胞周期的关系、DNA损伤与修复在神经元死亡机制中的作用以及在脑缺血时DNA损伤与修复相关基因表达的研究进展 DNA damage repair of cells and tissues is the main reason that affects cell survival and death. Currently, DNA damage and repair play an important role in the mechanism of ischemic neuronal death. This article mainly expounds the molecular mechanism of DNA damage repair, the relationship with cell cycle, the role of DNA damage and repair in the mechanism of neuronal death, and the research progress of DNA damage and repair-related gene expression in cerebral ischemia