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临床上鉴别非特异性溃疡性结肠炎(简称UC)和Crohn结肠炎(简称CC)有时较困难,这两种结肠炎可认为是临床上不同类型的炎症性肠病(简称IBD)。目前对IBD的病因和发病机制尚未完全明确,治疗仍不够理想。de Dombal等对CC病人采用内科保守治疗之疗效未能肯定,而CC病人外科手术的疗效亦很差,CC与UC二者用同样的内科治疗,其疗效亦略有不同。近二十年来胃肠道免疫学有较大发展,胃肠道也是体液和细胞免疫反应的重要场所,IBD可能为免疫反应或自身免疫反应所引起。Hodgson等报告UC与CC病人血清中IgG、IgM均有明显增高,特别是IgM,在应用皮质类固醇治疗时增高,治疗停止后即明显下降。IBD患者血清中C_3和C_4含量亦增高,有些
It is sometimes difficult to identify nonspecific ulcerative colitis (UC) and Crohn’s colitis (CC) clinically, and these two colitis can be considered as clinically different types of inflammatory bowel disease (IBD). At present, the etiology and pathogenesis of IBD have not yet been completely clear, the treatment is still not ideal. de Dombal and other patients with CC in the conservative treatment of the efficacy of medical treatment can not be sure, and the efficacy of surgical treatment of patients with CC is poor, both CC and UC with the same medical treatment, the effect is also slightly different. Gastrointestinal immunology has been greatly developed in recent two decades. Gastrointestinal tract is also an important site for humoral and cellular immune responses. IBD may be caused by immune response or autoimmune reaction. Hodgson and other reports of UC and CC patients serum IgG, IgM were significantly higher, especially IgM, increased in the application of corticosteroids, the treatment decreased significantly after stopping. IBD serum levels of C_3 and C_4 also increased, some