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目的:探讨妊娠期高血压疾病产妇剖宫产术前应用盐酸戊乙奎醚对胎儿及产妇的影响。方法:将200例择期妊娠期高血压疾病产妇剖宫产术随机分为阿托品(A组)和盐酸戊乙奎醚组(C组)各100例,C组术前肌注盐酸戊乙奎醚0.5mg,A组术前肌注阿托品0.5 mg。观察两组HR、收缩压(SBP)、心脏每搏输出量(SV)、心排血指数(CI),口干程度视觉模拟评分(VAS)、寒战及新生儿1和5 min Apgar评分。结果:A组给药后HR、SBP、SV、CI明显高于给药前,差异有统计学意义(P<0.05),C组各时点SBP均较给药前显著降低,差异有统计学意义(P<0.05),但均在正常范围内;C组给药后HR、SV、CI与给药前比较差异无统计学意义(P>0.05)。A组有42例寒战反应,C组无寒战反应,差异有统计学意义(P<0.05)。两组给药后VAS评分、新生儿1和5 min Apgar评分差异无统计学意义(P>0.05)。结论:盐酸戊乙奎醚可安全用于妊娠期高血压疾病剖宫产术前用药。
Objective: To investigate the effect of penehyclidine hydrochloride on fetus and maternal before cesarean section in hypertensive disorder complicating pregnancy. Methods: A total of 200 cesarean sections were randomly divided into atropine group (A group) and penehyclidine hydrochloride group (C group) in each group. C group was given intraoperative intramuscular injection of penehyclidine hydrochloride 0.5mg, A group before intramuscular injection of atropine 0.5 mg. The HR, systolic blood pressure (SBP), cardiac output (SV), cardiac output index (CI), visual analogue score (VAS) of dry mouth, chills and Apgar scores at 1 and 5 min of neonates were observed. Results: The HR, SBP, SV and CI in group A were significantly higher than those before administration (P <0.05), and the SBP in group C at each time point was significantly lower than that before administration (P <0.05), but all were within the normal range. There was no significant difference in HR, SV and CI between before and after administration in group C (P> 0.05). There were 42 chills in group A and no chills in group C, the difference was statistically significant (P <0.05). There was no significant difference in VAS scores between two groups after administration, Apgar scores at 1 and 5 min of neonates (P> 0.05). Conclusion: Penehyclidine hydrochloride can be safely used in the preoperative cesarean section of gestational hypertension.