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本研究报道动脉硬化性脑梗塞患者和TIA患者血浆组织型纤溶酶原激活物(t—PA)含量、活性及其抑制物(PAI)活性在缺血性脑卒中发病后一段时间内的动态变化.结果表明脑梗塞患者血浆t—PA活性显著下降,而PAI活性却在同期增高.病后第4周PAI活性趋于恢复.本研究结果提示脑梗塞患者存在显著的纤溶激活功能异常,纠正此类异常可能是治疗脑缺血的重要措施之一.
This study reports the dynamic changes of plasma tissue-type plasminogen activator (t-PA) activity and its inhibitor (PAI) activity in patients with arteriosclerotic cerebral infarction and TIA after a period of onset of ischemic stroke The results showed that plasma t-PA activity decreased significantly in patients with cerebral infarction, while the activity of PAI increased at the same period.After 4 weeks the PAI activity tended to recover.The results suggest that patients with cerebral infarction have significant fibrinolytic activation abnormalities, To correct such abnormalities may be one of the important measures to treat cerebral ischemia.