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目的:探讨应激性高血糖(SHG)与危重患者血硒及谷胱甘肽过氧化物酶活性之间的关系。方法:回顾分析25例应激性高血糖危重患者(SHG组)与未发生应激性高血糖危重患者17例(对照组)血硒水平、全血谷胱甘肽过氧化物酶活性(GSH-PX)活性。结果:SHG组血硒水平(54.3±21.5)μg/L,GSH-PX活性(57.12±13.21)单位;对照组血硒水平(61±24.15)μg/L,GSH-PX活性(64.12±11.10)单位。p<0.01,两组对比差异有统计学意义。且血硒水平与GSH-PX活性呈正相关(r=0.68,p<0.01)。结论:危重患者的血硒水平下降影响了GSH-PX活性并与应激性高血糖的发生相关。
Objective: To investigate the relationship between stress hyperglycemia (SHG) and blood selenium and glutathione peroxidase activity in critically ill patients. Methods: The levels of selenium, total glutathione peroxidase (GSH) in blood of 25 critically ill patients with stress hyperglycemia (SHG group) and 17 critically ill patients without stress hyperglycemia (control group) were retrospectively analyzed. -PX) activity. Results Selenium levels (54.3 ± 21.5) μg / L and GSH-PX activities (57.12 ± 13.21) in SHG group were significantly higher than those in SHG group (61 ± 24.15 μg / L, 64.12 ± 11.10, unit. p <0.01, the difference between the two groups was statistically significant. Blood selenium levels were positively correlated with GSH-PX activity (r = 0.68, p <0.01). CONCLUSIONS: Selenium levels in critically ill patients affect GSH-PX activity and correlate with stress hyperglycemia.