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目的:优选鼻渊口服液的制备工艺,制备质量稳定的鼻渊口服液。方法:以辛夷、细辛、薄荷、白芷挥发油的提取量,白芷中欧前胡素含量为指标,采用正交试验设计,优先最佳提取工艺。结果:辛夷、细辛、薄荷、白芷以粗粉浸泡2h,加8倍量水,蒸馏提取6h收率最高。白芷依生产实际,以8倍量水,回流煮提3次,每次1h为最佳工艺。配制用增溶剂为吐温-80,适用浓度为0.2%,pH范围3.5～5.5稳定,灭菌条件为流通饱和蒸气100℃、30min灭菌。结论:试验结果可靠,本工艺条件用于鼻渊口服液的制备具较好的效果。
Objective: To optimize the preparation process of nasopharyngeal oral liquid and to prepare nasosinus oral solution with stable quality. Methods: Taking the extract of volatile oil of Magnolia bark, asarum, mint, Angelica dahuricae and the content of Imperatorin in Angelica dahuricae as indexes, orthogonal design was adopted to optimize the extraction process. Results: Magnolia bark, Asarum, mint, Angelica to coarse powder soak 2h, add 8 times the amount of water, distilled 6h highest yield. Angelica according to the actual production, 8 times the amount of water, boiling back to mention 3 times, each 1h for the best technology. The preparation of the solubilizer Tween-80, the applicable concentration of 0.2%, pH range of 3.5 to 5.5 stable, sterile conditions saturated steam circulation 100 ℃, 30min sterilization. Conclusion: The test results are reliable, the process conditions for the preparation of nasal cavity oral solution with good results.