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目的:探讨鼻呼出气一氧化氮值(NNO)对睡眠呼吸障碍(SDB)儿童诊断的临床意义,评估SDB儿童气道炎症的严重程度。方法:选取SDB患儿30例、健康儿童20例为研究对象,用瑞典NIOX MINO仪器无创检测受试者的NNO值。以SPSS 20.0统计软件进行数据分析。结果:与健康儿童相比,SDB患儿的NNO值升高,差异有统计学意义(Z=-2.215,P<0.05)。在SDB患儿中,NNO值与其AHI值呈正相关(r=0.429,P<0.05),与夜间最低血氧值呈负相关(r=-0.482,P<0.01),与其他睡眠参数无相关性。结论:NNO值是反映SDB患儿气道炎症严重程度的潜在指标。
Objective: To investigate the clinical significance of nasal exhaled nitric oxide (NNO) in diagnosis of children with sleep disordered breathing (SDB) and to evaluate the severity of airway inflammation in SDB children. Methods: Thirty children with SDB and 20 healthy children were enrolled in this study. The NNO of non-invasive test subjects was detected by Swedish NIOX MINO instrument. SPSS 20.0 statistical software for data analysis. Results: Compared with healthy children, the NNO value of SDB children increased, the difference was statistically significant (Z = -2.215, P <0.05). There was a positive correlation between NNO and AHI (r = 0.429, P <0.05) and negative correlation with nocturnal oxygen saturation (r = -0.482, P <0.01) in SDB children and no correlation with other sleep parameters . Conclusion: The NNO value is a potential indicator of the severity of airway inflammation in SDB children.