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钙通道阻滞剂(Calcium-channel block-ers CCB)为一类化学结构不同的物质,它们均具有抑制 Ca~(++)在动作电位期间通过慢通道进入纲胞的作用。目前已有20余种,最常见的有异搏定、硝苯吡啶、硫氮■酮等,临床上主要用于治疗心血管病如冠心病、高血压病和某些心律失常(室上性心动过速)等。然而,近几年的研究表明,一些非心血管疾病的病理变化也是由于细胞内 Ca~
Calcium-channel blockers (CCBs) are a group of substances with different chemical structures. They all have the effect of inhibiting Ca ++ (++) from entering the cells through the slow channel during the action potential. There are currently more than 20 species, the most common verapamil, nifedipine, thiaminone, etc., clinically used mainly for the treatment of cardiovascular diseases such as coronary heart disease, hypertension and certain arrhythmias (supraventricular Tachycardia) and so on. However, in recent years, studies have shown that some pathological changes in non-cardiovascular disease is also due to intracellular Ca ~