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以前报道潘生丁的半衰期(t1/2)为0.5～2.5小时,常规服法每日三次。但近来发现本品半衰期约12小时,临床上也观察到慢性病长期服用时有蓄积现象。作者对照了20名服用潘生丁的患者(男18,女2;平均年龄54±9岁),总剂量都是150mg/日。服用方法有两种,Ⅰ组为每日三次,每次50mg;Ⅱ组为每日两次,每次75mg。在服后的2小时(峰值)及首次剂量后的8小时或12小时采集血样,3～6天后重测。血药浓度用高效液相层析法测定。共研究了27个曲线,CV为8.2±±3.4%。结果Ⅰ组达到稳定状态时,平均峰值浓度为1.40±0.72μg/ml,谷值浓度为0.85±0.5μg/ml(开始);0.72±0.39μg/ml(最终),蓄积因素为2.73,t1/2为10.1小时。药物浓度在病人中有很大波动,峰值浓
The half-life of dipyridamole (t1 / 2) was previously reported to be 0.5 to 2.5 hours, with routine administration three times daily. But recently found that the half-life of this product is about 12 hours, clinically observed long-term chronic disease accumulation. The authors compared 20 patients taking dipyridamole (male 18, female 2; mean age 54 ± 9 years) with a total dose of 150 mg / day. There are two ways to take, Ⅰ three times a day, each 50mg; Ⅱ twice daily, each 75mg. Blood samples were taken at 2 hours (peak) and 8 hours or 12 hours after the first dose and retest after 3 to 6 days. Plasma concentrations were determined by high performance liquid chromatography. A total of 27 curves were studied with a CV of 8.2 ± ± 3.4%. Results In group Ⅰ, the average peak concentration was 1.40 ± 0.72μg / ml and the trough concentration was 0.85 ± 0.5μg / ml (start); 0.72 ± 0.39μg / ml (final), the accumulation factor was 2.73, t1 / 2 is 10.1 hours. Drug concentration in patients with great fluctuations, the peak concentration