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观察31例原发性肾病综合征,合并高凝状态者14例(占45.16%),高凝状态的诊断依据是:(1)实验室指标,主要是血纤维蛋白原增高,其次尿FDP 阳性及血小板增高;(2)应用抗凝或抗血小板聚集药物能有效地减少血栓形成;(3)个别病例可无实验室检测依据,需结合临床并应用抗凝治疗有效者而证实诊断。抗高凝状态的治疗包括应用肝素、潘生丁、低分子右旋醣酐等抗凝抗血小板聚集药物治疗。认为抗凝治疗能起到一般利尿、降压药物难以达到的预期效果,而在抗凝治疗基础上能提高机体对激素的敏感性,但并无直接降低尿蛋白的作用。
Thirty-one cases of primary nephrotic syndrome were observed. Among them, 14 cases (45.16%) had hypercoagulable state. The diagnosis of hypercoagulable state was based on (1) laboratory indexes, mainly increased fibrinogen, followed by positive urine FDP And thrombocytopenia; (2) the use of anticoagulant or anti-platelet aggregation drugs can effectively reduce thrombosis; (3) individual cases can be no laboratory test based on the need to combine clinical and anticoagulant therapy to confirm the diagnosis. Treatment of anti-hypercoagulable state, including the application of heparin, dipyridamole, low molecular weight dextran anticoagulant anti-platelet aggregation drug treatment. That anticoagulant therapy can play a general diuretic, antihypertensive drugs is difficult to achieve the desired effect, and in the anticoagulation therapy can improve the body’s sensitivity to hormones, but did not directly reduce the role of urinary protein.