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一般认为六价铬是致癌物质,也是生物细胞染色体的诱变物质。关于铬化合物对动物细胞染色体的影响国外已有实验报导,但这些报道所用实验方法多为体外实验(in vitro),而体内实验(in vivo)很少。最近国内有“八种毒物混合致小鼠骨髓染色体畸变”的报道,认为哺乳动物染色体畸变率分析是铬化合物对机体影响的较灵敏指标之一。它可预示肿瘤的发生,同时也可作遗传潜在危险的信号。有人报道常接触铬化合物的工人其外周血淋巴细胞发生染色体畸变率比对照组高些,而且随着接
Hexavalent chromium is generally considered to be a carcinogen and a mutagenic substance for chromosomes of biological cells. The effect of chromium compounds on the chromosomes of animal cells has been reported abroad, but the experimental methods used in these reports are mostly in vitro and in vivo. Recently, there are reports of “eight bone marrow chromosome aberrations caused by mixed mouse poisons” in China. It is believed that the chromosome aberration rate analysis in mammals is one of the more sensitive indicators of the effects of chromium compounds on the body. It can predict the occurrence of tumors, and it can also serve as a signal of genetic potential danger. It has been reported that the frequency of chromosomal aberrations in peripheral blood lymphocytes of workers exposed to chromium compounds is higher than that of the control group, and