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磺苯咪唑(Sulmazole.Sul AR-L115 BS)系新型的非强心甙类非儿茶酚胺类强心药.兼有正性肌力作用和血管扩张作用。国外80年代初对其药效学的研究已有大量报道.发现有的文献中提及该药可使大小白鼠诱发肝癌。国内80年代亦将该药合成。本文以小鼠骨髓多染红细胞(PCE)微核试验观察了国产Sul的诱变活性。
Sulbenzole (Sulmazole.Sul AR-L115 BS) is a new non-cardiac glycosides non-catecholamine cardiac medicine, both positive inotropic effect and vasodilation. Abroad in the early 1980s on its pharmacodynamics has been a large number of reports.It was found in some literature mentioned that the drug can induce liver cancer in rats and rats. The domestic 80’s also synthesized the drug. In this paper, mouse bone marrow polychromatic erythrocyte (PCE) micronucleus test domestic Sul mutagenic activity was observed.