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辅酶 Q(CoQ)是一类脂溶性醌,广泛存在于生物界,故称为泛醌。据近年研究,在实验性心肌缺血,阿霉索引起的心肌病变,以及充血性心力衰竭时,心肌内 CoQ_(10)的含量较正常为低。CoQ_(10)是细胞内线粒体呼吸链的一个组分,在电子传递系统中位于 NADH 脱氢酶(Complex Ⅰ)或琥珀酸脱氢酶(Complex Ⅱ)两个黄索蛋白与细胞色素 b—C_1复合物(Complex Ⅲ)之间,CoQ 为电子传递系统中的递氢体,是生成ATP 的必需成份。CoQ 缺乏时使得电子传
Coenzyme Q (CoQ) is a fat-soluble quinone, widely found in the biological world, it is called ubiquinone. According to recent studies, the content of CoQ_ (10) in myocardium is lower than normal in experimental myocardial ischemia, cardiomyopathy caused by adriamycin, and congestive heart failure. CoQ_ (10) is a component of the mitochondrial respiratory chain in the cell. In the electron transport system, CoQ_ (10) is located between NADH dehydrogenase (Complex Ⅰ) and succinate dehydrogenase (Complex Ⅱ) Complex (Complex III), CoQ is a hydrogen transporter in the electron transport system and is an essential element in ATP production. When the lack of CoQ makes electronic transmission