糖尿病下肢大血管病变是糖尿病所导致的大血管病变在下端肢体的具体体现,在祖国医学领域其病机为本虚标实,本虚为气阴两虚;标实为下肢远端的瘀血,本文列举了从家兔、大鼠、小鼠、猪等动物进行糖尿病下肢大血管病变进行造模,以及其糖尿病瘀血证的生物评价方法,为该方向的研究提供总结借鉴意义。 Diabetic lower extremity macrovascular disease is a large vascular disease caused by diabetes in the lower extremity of the concrete manifestation of the motherland in the field of disease-based virtual standard real virtual, virtual Qi and Yin Deficiency; standard real lower extremity bleeding , This article lists the biological evaluation methods of diabetic lower extremity macrovascular disease in rabbits, rats, mice and pigs, as well as their biomarkers of diabetes stasis syndrome, and provides a summary of the research for this direction.