Gastroesophageal reflux disease(GERD) is a frequen disorder which is expensive to diagnose and treat Initiating therapy with empiric trial of proton-pump inhibitor is a well established strategy; however symptoms of GERD do often persist regardless of effective medication. Nowadays, increasing interest concerning the efficacy and safety of chronic acid suppression with proton-pump inhibitors(PPIs), prompts a consideration fo GERD treatment strategies related to the basic physiology of the lower esophageal sphincter, including modulationof its tone and ending of spontaneous transient lower esophageal sphincter relaxation, which contributes to reflux. Together, the lower esophageal sphincter and the crural diaphragm represent the major antireflux barrier, protecting the esophagus from reflux of gastric content. In order to prevent the need for enduring PPIs therapy or surgical procedures, substitute therapeutics approaches are being researched. Recently, studies have focused on the response of the respiratory muscles to inspiratory muscle training. As a result, inspiratory muscle training has emerged as a potential alternative for treatment of gastroesophageal reflux. The present report reviews the physiologic factors contributing to GERD, and presents the newly developed therapies that can be applied either alone or in association with available efficient GERD therapy. Gastroesophageal reflux disease (GERD) is a frequen disorder which is expensive to diagnose and treat Initiating therapy with empiric trial of proton-pump inhibitor is a well established strategy; yet symptoms of GERD do often persist regardless of of services. Nowadays, the efficacy and safety of chronic acid suppression with proton-pump inhibitors (PPIs), prompts a consideration fo the GERD treatment strategies related to the basic physiology of the lower esophageal sphincter, including modulation of its tone and ending of spontaneous transient lower esophageal sphincter relaxation, which Together, the lower esophageal sphincter and the crural vial represent the major antireflux barrier, protecting the esophagus from reflux of gastric content. In order to prevent the need for enduring PPIs therapy or surgical procedures, substitute therapeutics approaches are being researched. Recently, studies have focused on the respo nse of the respiratory muscles to inspiratory muscle training. As a result, inspiratory muscle training has emerged as a potential alternative for treatment of gastroesophageal reflux. The present report reviews the physiologic factors contributing to GERD, and presents the newly developed therapies that can be applied either alone or in association with available efficient GERD therapy.