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耳聋是老年人四种最主要的慢性疾病之一。尽管流行性较高,但年龄相关性听力受损的生物学基础还不清楚。本文研究目的旨在确定年龄相关性听力受损是否与VitB_(12)缺乏,叶酸缺乏或二者同时缺乏有关。对象与方法选择志愿者55人,年龄60～71岁,均为健康女性。排除有糖尿病、卒中、耳病、噪音性耳聋、单侧耳聋等病史患者。年龄相关性听力受损,即老年性耳聋是50岁后发生的双侧感觉神经听力受损,在排除其它可能病因后即可诊断。听力功能测定按0.5-,1-,2-和4-KHZ气导纯音平均听阈确定,可分为以下两组:听力正常,<20dB听力水平(n=38～44):听力受损,≥20dB听力水平(n=10～11)。于过夜禁食后7:30到10:00采血,
Deafness is one of the four major chronic diseases in the elderly. Despite the high prevalence, the biological basis of age-related hearing loss remains unclear. The purpose of this study was to determine if age-related hearing impairment is associated with a deficiency of VitB 12, folic acid deficiency, or both. Subjects and methods Select volunteers 55 people, aged 60 to 71 years old, are healthy women. Exclude patients with diabetes, stroke, ear disease, noise deafness, unilateral deafness and other history. Age-related hearing impairment, that is, senile deafness occurs after the age of 50 bilateral hearing loss sensory nerves in the exclusion of other possible causes can be diagnosed. The hearing function was determined by the average hearing threshold of 0.5-, 1-, 2- and 4-KHZ guided pure tone, which can be divided into the following two groups: normal hearing, <20dB hearing level (n = 38-44) 20dB hearing level (n = 10 ~ 11). After overnight fasting 7:30 to 10:00 blood collection,