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Dauricine 8 mg/kg was found to be effec-tive in antagonizing arrhythmias induced bychloroform and adrenaline in rabbits.It raisedthe ventricular fibrillation-inducing and lethaldoses of ouabain in guinea pigs with an effective-heSS similar to tetrandrine.It also significantlyraised the arrhythmia-inducing and lethal dosesof acontitine in rats and elevated the electricalveutricular fibrillation threshold in cats.Tetran-driue did not do either.Experimental results in-dicate that the antiarrhythmic action of dauri-cine is extensive and that its mode of action isnot identical with that of tetrandrine.
Dauricine 8 mg/kg was found to be effec-tive in antagonizing arrhythmias induced bychloroform and adrenaline in rabbits.It raisedthe ventricular fibrillation-inducing and lethaldoses of ouabain in guinea pigs with an effective-heSS similar to tetrandrine.It also significantlyraised the arrhythmia- Inducing and lethal dosesof acontitine in rats and elevated the electricalveutricular fibrillation threshold in cats.Tetran-dried did not do either.Experimental results in-dicate that the antiarrhythmic action of dauri-cine is extensive and that its mode of action is not identical with that of Tetrandrine.