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目的:探讨乳腺癌浸润性导管癌组织中MMP-9及AnnexinⅡ蛋白的表达及其意义。方法:应用免疫组织化学SP法检测60例乳腺纤维腺瘤组织及60例乳腺浸润性导管癌组织中MMP-9和AnnexinⅡ蛋白的表达,并分析二者与乳腺癌临床病理特征的关系。结果:MMP-9和AnnexinⅡ蛋白在浸润性导管癌中的表达率分别是86.67%(52/60)及90.00%(54/60),明显高于在乳腺纤维腺瘤组织中的表达率,且差异均有统计学意义(P<0.001);在伴有淋巴结转移的浸润性导管癌组织中MMP-9和AnnexinⅡ蛋白的表达率明显高于无淋巴结转移组,差异均有统计学意义(P=0.003;P=0.023),组织学分级越低二者蛋白的表达越高(P=0.003;P=0.023)。结论:人乳腺浸润性导管癌组织中MMP-9和AnnexinⅡ蛋白的异常表达与肿瘤的浸润转移密切相关。
Objective: To investigate the expression and significance of MMP-9 and AnnexinⅡ in invasive ductal carcinoma of breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of MMP-9 and Annexin Ⅱ in 60 cases of breast fibroadenoma and 60 cases of infiltrating ductal breast cancer. The relationship between them and the clinicopathological features of breast cancer was analyzed. Results: The positive rates of MMP-9 and AnnexinⅡ in invasive ductal carcinoma were 86.67% (52/60) and 90.00% (54/60), respectively, which were significantly higher than those in breast fibroadenoma (P <0.001). The expression rates of MMP-9 and AnnexinⅡprotein in invasive ductal carcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis (P = 0.003; P = 0.023). The lower the histological grade was, the higher the protein expression was (P = 0.003; P = 0.023). Conclusion: The abnormal expression of MMP-9 and AnnexinⅡ in human breast invasive ductal carcinoma is closely related to the invasion and metastasis of tumor.