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目的探讨热毒宁注射液佐治婴幼儿急性轮状病毒性肠道感染的疗效。方法选择2013年3月-2014年3月儿科门诊的180例急性肠道感染患儿。门诊常规进行粪便轮状病毒检测,根据就诊次序分成治疗组与对照组各90例。在常规治疗基础上,治疗组加用热毒宁注射液0.5~0.8ml·kg-1·d-1,对照组加用利巴韦林10ml·kg-1·d-1,连用3d。结果 180例患儿病毒检测阳性率61.7%(111/180),其中治疗组为63.3%,对照组为60.0%,差异无统计学意义(P>0.05)。治疗组大便次数,大便性状,一般情况等改善均优于对照组,疗程短于对照组,差异有统计学意义(P<0.05)。结论热毒宁注射液佐治婴幼儿急性病毒性肠道感染疗效好且不增加患者经济负担。
Objective To investigate the therapeutic effect of Rendunning injection on acute rotavirus infection in infants and young children. Methods From March 2013 to March 2014, 180 pediatric patients with acute intestinal infections were selected as pediatric outpatients. Outpatient routine detection of stool rotavirus, according to the order of treatment was divided into treatment group and control group of 90 cases. On the basis of conventional treatment, the treatment group plus Renduining injection 0.5 ~ 0.8ml · kg-1 · d-1, the control group plus ribavirin 10ml · kg-1 · d-1, used in combination for 3d. Results The positive rate of virus detection in 180 children was 61.7% (111/180), of which 63.3% in treatment group and 60.0% in control group, the difference was not statistically significant (P> 0.05). The stool frequency, stool trait and general situation in the treatment group were better than those in the control group, and the treatment duration was shorter than that in the control group (P <0.05). Conclusion Revedunin injection adjuvant treatment of acute viral intestinal infections in infants and young children is effective and does not increase the financial burden on patients.