以前报告的酒精性脊髓病几乎均发生于肝硬化伴手术或门脉分流后的病人,多数病人有反复发生的肝性脑病。脊髓病常常在脑病发生以后出现。本文报告5例酒精性脊髓病病人没有严重的肝脏疾病、肝性脑病或明显的神经病,也缺乏门腔静脉分流或显著的肝机能障碍。其中男4例,女1例,年龄53～63岁。临床表现为进行性脊髓后索和侧索功能障碍综合征,首发症状为双足进行性感觉异常,在以后的1～4年间呈现进行性痉挛性共济失调,无泌尿道机能不全和上肢症状,无中毒和痉挛性轻瘫家族史。每例至少有15年的饮酒史,每天饮酒均在270ml 以上。神经系统检查显示痉挛性轻瘫,双下肢反射亢进,阳性巴彬斯基氏征,足趾震动觉及位置觉减退,上肢肌力和肌张力正常。痛、触觉、精神状态、颅神经 Allergic myelopathy reported in the past almost all occurred in cirrhosis with surgery or portal shunt after the patient, most patients have recurrent hepatic encephalopathy. Myelopathy often occurs after encephalopathy. This article reports that 5 patients with alcoholic myelopathy did not have severe liver disease, hepatic encephalopathy or significant neuropathy, and also lacked portal venous shunts or significant liver dysfunction. Including 4 males and 1 female, aged 53 to 63 years. Clinical manifestations of progressive spinal cord and lateral dysfunction syndrome, the first symptom of bipolar progressive sensory abnormalities in the next 1 to 4 years showed progressive spastic ataxia, no urinary tract insufficiency and upper limb symptoms , Non-toxic and spastic paraparesis family history. Each case has at least 15 years of drinking history, daily drinking are more than 270ml. Nervous system examination showed spastic paresis, double lower extremity hyperreflexia, positive Babinski’s sign, toe vibration and position feel subsided, upper limb muscle strength and muscle tone normal. Pain, touch, mental state, cranial nerves