【摘 要】
：
Two novel styryllactones,goniodilactone(1) and gonioheptenolactone(2),were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determi
【机 构】
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Division of Medicinal Chemistry and Natural Products,School of Pharmacy,University of North Carolina
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Two novel styryllactones,goniodilactone(1) and gonioheptenolactone(2),were isolated from the leaves of Goniothalamus cheliensis Hu.Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 exhibited significant cytotoxicities in a panel of human cancer cells,including DU-145,PC-3,MCF-7,A-549, KB and KBvin,with GI_(50)S in the range of 1.29-4.56μg/mL.
Two novel styryllactones, goniodilactone (1) and gonioheptenolactone (2), were isolated from the leaves of Goniothalamus cheliensis Hu. Their structures were determined on the basis of spectroscopic data as well as X-ray crystallography analysis. Compounds 1 and 2 schematically significant cytotoxicities in a panel of human cancer cells, including DU-145, PC-3, MCF-7, A-549, KB and KBvin with GI_ (50) S in the range of 1.29-4.56 μg / mL.
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