趋化因子是当今细胞因子研究领域的热点之一,而调节活化正常T细胞表达与分泌的趋化因子(RAN-TES)是CC型趋化因子成员。近来许多研究发现它与多种免疫及炎症反应、肿瘤转移等密切相关。在刺激因素的作用下,可以通过MAPK、NF-κB、JAK-STAT和PKC等信号通路诱导RANTES基因的表达。本文就有关这方面的研究进展做一综述。 Chemokines are one of the hot topics in the field of cytokine research, and chemotactic factor (RAN-TES), which regulates the expression and secretion of activated normal T cells, is a member of CC chemokines. Recently, many studies have found that it is closely related to various immune and inflammatory reactions and tumor metastasis. Under the stimulus, the expression of RANTES gene can be induced by MAPK, NF-κB, JAK-STAT and PKC signaling pathway. This article reviews the research progress in this area.