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目的:探讨Yes-相关蛋白(Yes-associated protein,YAP)在肾癌(Renal Cell Carcinoma,RCC)组织中的表达及其与肾癌生物学行为的关系。方法:半定量免疫组织化学法检测YAP在RCC组织及良性病变肾组织中的表达,分析其与RCC生物学行为的关系。结果:YAP在良性病变肾组织中的表达率为35.0%(7/20),明显低于RCC组织中的表达率78.7(59/75),差异具有统计学意义(X2=14.196,P<0.05);YAP的表达与患者的性别、年龄、肿瘤直径大小及肾静脉是否受侵无明显关联(P>0.05);但与肿瘤分化程度、TNM分期及有无淋巴结转移显著相关,差异具有统计学意义(P<0.05)。结论:YAP在RCC组织中呈高表达,可能参与了RCC的发生及进展。
Objective: To investigate the expression of Yes-associated protein (YAP) in Renal Cell Carcinoma (RCC) and its relationship with the biological behavior of renal cell carcinoma. Methods: Semiquantitative immunohistochemical method was used to detect the expression of YAP in RCC tissue and benign lesion renal tissue, and to analyze its relationship with the biological behavior of RCC. Results: The positive rate of YAP expression in benign lesions was 35.0% (7/20), which was significantly lower than that in RCC tissues (78.7% vs 59.7%, P <0.05) ). There was no significant correlation between YAP expression and patient’s sex, age, tumor diameter and renal vein invasion (P> 0.05), but there was significant correlation between YAP expression and tumor differentiation, TNM stage and lymph node metastasis Significance (P <0.05). Conclusion: YAP is highly expressed in RCC tissues and may be involved in the occurrence and progression of RCC.