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目的检测2型糖尿病肾病患者不同时期血浆C反应蛋白(CRP)值,探讨CRP与2型糖尿病肾病的相关性。方法 216例2型糖尿病患者按尿白蛋白排泄率和肌酐水平分为正常尿蛋白组56例,微量白蛋白尿组67例,大量尿蛋白组45例和终末期肾衰组48例,并设健康对照组60例。免疫比浊法测定各组CRP值,分析CRP在各组的差异性以探讨CRP与糖尿病肾病的关系。结果 2型糖尿病各组血清CRP水平与对照组相比明显升高,而且其水平随蛋白排泄率的升高而升高(P<0.05)。多因素相关分析显示,CRP与病程(r=0.656,P<0.05)、肌酐(Cr)(r=0.424,P<0.05)、UAER(r=0.681,P<0.05)呈显著正相关。结论 CRP与糖尿病肾病的病情呈正相关,CRP可作为2型糖尿病肾病患者病情监测的新指标。
Objective To detect plasma C-reactive protein (CRP) in patients with type 2 diabetic nephropathy at different periods and to explore the correlation between CRP and type 2 diabetic nephropathy. Methods 216 patients with type 2 diabetes mellitus were divided into urinary albumin excretion rate and creatinine level in 56 cases of normal urine protein group, 67 cases of microalbuminuria group, 45 cases of large urine protein group and 48 cases of end-stage renal failure group, and Healthy control group of 60 cases. Immunoprecipitation assay CRP values in each group, CRP analysis of the differences in each group to explore CRP and diabetic nephropathy. Results Serum CRP levels in each group were significantly higher than those in control group, and their levels increased with the increase of protein excretion rate (P <0.05). Multivariate analysis showed that there was a significant positive correlation between CRP and duration of disease (r = 0.656, P <0.05), creatinine (Cr = 0.424, P <0.05) and UAER (r = 0.681, P <0.05). Conclusion CRP is positively correlated with diabetic nephropathy and CRP may be used as a new indicator of disease surveillance in patients with type 2 diabetic nephropathy.