论文部分内容阅读
目的采用基于磁共振成像的全脑皮层厚度分析方法研究2型糖尿病患者脑部皮层厚度的异常变化。方法对16名新发2型糖尿病患者及16名健康志愿者行高分辨三维T1快速毁损梯度回波成像。基于Freesurfer软件(4.3.0版)计算全脑皮层厚度图,并采用基于脑回的感兴趣区法计算各个脑区的皮层厚度。以年龄和性别作为协变量进行协方差分析比较各个脑区的平均皮层厚度。采用基于表面的皮层厚度分析法在全脑水平比较皮层厚度的局部差异。结果 2型糖尿病患者双侧大脑皮层厚度(左侧:2.52±0.07 mm;右侧:2.51±0.08 mm)较对照组(左侧:2.56±0.09 mm;右侧:2.56±0.09 mm)变薄(P<0.05)。2型糖尿病患者较正常对照组局部脑回变薄的脑区主要位于旁中央叶、中央后回、枕外侧回、舌回、楔前回、颞上回、颞中回、颞下回及后扣带回。左侧中扣带回及右侧颞下回皮层厚度与2型糖尿病病程呈负相关。结论新发2型糖尿病患者可发生脑部广泛皮层变薄。本研究结果证实了2型糖尿病可导致脑部微小结构发生改变。
Objective To investigate the abnormal changes of cerebral cortex thickness in patients with type 2 diabetes using magnetic resonance imaging-based whole-cerebral cortex thickness analysis. Methods Sixteen newly diagnosed type 2 diabetic patients and 16 healthy volunteers underwent high resolution three-dimensional T1 rapid grasping gradient echo imaging. Whole cerebral cortical thickness maps were calculated based on Freesurfer software (version 4.3.0) and cortical thickness in each brain region was calculated using the brain-based region of interest method. Covariance analysis using age and gender as covariates compared mean cortical thickness in all brain regions. Local differences in cortical thickness were compared at the whole brain level using surface-based cortical thickness analysis. Results The bilateral cerebral cortex thickness (left side: 2.52 ± 0.07 mm; right side: 2.51 ± 0.08 mm) in patients with type 2 diabetes was thinner than that of the control group (left side: 2.56 ± 0.09 mm; right side: 2.56 ± 0.09 mm) P <0.05). Patients with type 2 diabetes than the normal control group of local brain thinning of the brain area is mainly located in the next to the central lobe, central back, occipital lateral gyrus, tongue back, wedge anterior, superior temporal gyrus, temporal back, infratemporal and posterior Bring back The left cingulate gyrus and right inferior temporal cortex were negatively correlated with the duration of type 2 diabetes. Conclusion New type 2 diabetes patients can occur in the extensive brain cortex thinning. The results of this study confirm that type 2 diabetes leads to changes in the micro-structure of the brain.