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目的 探讨不同时期糖尿病肾病患者血清肿瘤坏死因子(TNF)水平。方法 采用放射免疫法测定34例糖尿病(DM)、19例早期糖尿病肾病(DN)、19例临床期DN患者的TNF含量并与正常组对照。结果 早期DN组及临床期DN组TNF均显著高于正常对照组(P<0.05,0.01),DM组与正常对照组比较差异无显著意义(P>0.05)。结论 TNF可能在DN的发生发展过程中起重要作用。
Objective To investigate the levels of serum tumor necrosis factor (TNF) in patients with diabetic nephropathy at different stages. Methods Radioimmunoassay was used to determine the level of TNF in 34 diabetic patients (DN), 19 early diabetic nephropathy (DN) and 19 DN patients and compared with the normal control group. Results The TNF in early DN group and clinical DN group was significantly higher than that in normal control group (P <0.05, 0.01). There was no significant difference between DM group and normal control group (P> 0.05). Conclusion TNF may play an important role in the development of DN.