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目的探讨术前不同剂量抗生素对结肠癌根治术患者术后恢复的影响。方法选取2013年4月至2015年5月在葫芦岛市中心医院普外行结肠癌根治术的99例患者,在基础肠道准备不变的情况下,按照术前服用抗生素的天数不同分为试验组51例,采取术前口服1天抗生素,即术前1天口服庆大霉素4mL+甲硝唑0.4g,日3次口服。对照组48例,术前2天口服庆大霉素4mL+甲硝唑0.4g,日3次口服。比较两组患者术后排气时间、切口感染、腹腔感染和腹泻人数等。结果试验组排气时间为(66.31±13.11)h,医疗费用(4.23±1.34)万元、切口感染率为1.96%,腹腔感染率为3.92%、腹泻率为5.89%,对照组排气时间为(90.31±13.12)h,医疗费用(4.92±1.41)万元、切口感染率为14.58%,腹腔感染率为18.75%、腹泻率为20.83%,组间比较差异有统计学意义(t=3.261、2.937,P<0.05;χ2=5.304、5.505、4.846,P<0.05),试验组优于对照组。结论对于结肠癌根治术的患者采用术前服用1天抗生素的模式,不仅降低医疗费用而且有助于术后恢复,减少感染的发生,值得在临床推广。
Objective To investigate the effect of different doses of antibiotics on the postoperative recovery of patients with colon cancer undergoing radical operation. Methods From April 2013 to May 2015, 99 patients who underwent radical resection of colon cancer in Huludao Central Hospital were divided into two groups according to the number of days preoperatively taking antibiotics when the basic intestinal preparation was the same Group of 51 cases, taking preoperative oral antibiotics 1 day, that is, oral administration of gentamicin 4mL + metronidazole 0.4g, 3 times daily orally. Control group of 48 patients, 2 days before gentamicin 4mL + metronidazole 0.4g, 3 times a day orally. The postoperative exhaust time, incision infection, abdominal infection and diarrhea were compared between the two groups. Results The exhaust time of the experimental group was (66.31 ± 13.11) h, the medical cost was 4.23 ± 1.34 million, the incision infection rate was 1.96%, the rate of abdominal infection was 3.92% and the rate of diarrhea was 5.89% (90.31 ± 13.12) h, the cost of medical treatment was 4.92 ± 1.41 million, the incision infection rate was 14.58%, the rate of abdominal infection was 18.75% and the rate of diarrhea was 20.83%. There was significant difference between the two groups (t = 3.261, 2.937, P <0.05; χ2 = 5.304,5.505,4.846, P <0.05). The experimental group was better than the control group. Conclusion For patients with radical resection of colon cancer, taking a one-day preoperative antibiotic mode not only reduces medical costs but also helps postoperative recovery and reduce the incidence of infection, which is worthy of clinical promotion.