【摘 要】
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Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity.However,the inherent properties of these drugs,such as large molecular weight,poor stability,and conformational flexibi
【机 构】
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School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;College of Pharmacy,
论文部分内容阅读
Proteins and peptides have become a significant therapeutic modality for various diseases because of their high potency and specificity.However,the inherent properties of these drugs,such as large molecular weight,poor stability,and conformational flexibility,make them difficult to be formu-lated and delivered.Injection is the primary route for clinical administration of protein and peptide drugs,which usually leads to poor patient\'s compliance.As a portable,minimally invasive device,microneedles(MNs)can overcome the skin barrier and generate reversible microchannels for effective macromolecule permeation.In this review,we highlighted the recent advances in MNs-mediated transdermal delivery of protein and peptide drugs.Emphasis was given to the latest development in representative MNs design and fabrication.We also summarize the current application status of MNs-mediated transdermal protein and peptide delivery,especially in the field of infectious disease,diabetes,cancer,and other disease ther-apy.Finally,the current status of clinical translation and a perspective on future development are also provided.
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