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To investigate the structural form of gossypol and gossypolone Schiff’s bases,seven relevant Schiff’s bases were synthesized and the electrospray ionization-tandem mass spectrometry(ESI-MS/MS) with low-energy collision-induced dissociation was used to analyze their fragmentations.A common fragmentation pathway with the loss of RNH_2 from those schiff’s bases quasi-molecular ions was observed and proposed on the basis of their MS/MS spectra data.This common pathway indicated that those Schiff’s bases existed mainly as the enamine form not the imine form previously showed in most reports.
To investigate the structural form of gossypol and gossypolone Schiff bases, seven relevant Schiff bases were synthesized and the electrospray ionization-tandem mass spectrometry (ESI-MS / MS) with low-energy collision-induced dissociation was used to analyze their fragmentations. A common fragmentation pathway with the loss of RNH_2 from those schiff’s bases quasi-molecular ions was observed and proposed on the basis of their MS / MS spectra data. This common pathway indicates that those Schiff’s bases existed mainly as the enamine form not the imine form previously showed in most reports.