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选择16例孕龄无误,胎儿大小与孕龄相符,本次及既往妊娠无合并症者作为正常妊娠组,在28、32、34、36及38孕周时分别测定血浆雌三醇(E_3)、催乳素(hPL)、尿酸及Ⅷ因子相关抗原(ⅧRAg)/Ⅷ促凝活性(ⅧC)比,按平均值的±2个标准差作为正常范围;另21例可疑在临床上并发胎儿生长迟缓孕妇在诊断日起至分娩止检测上述各项指标。结果在可疑妊娠的21例中9例婴儿出生体重低于第10百分位,定为胎儿生长迟缓证实组,其平均体重为2.08kg;12例婴儿出生体重在第10百分位以上,定为胎儿生长迟缓未证实组,其平均体重为2.96kg,但比正常组的平均体重3.52kg仍有显著减低(p<0.001)。正常妊娠组血浆E_3水平自28～38孕周缓慢上升,而胎儿生长迟缓组E_3水平通常偏低,证实组在35次观察中有9次E_3值低于正常均数1个标准
16 cases of gestational age were selected correctly, the size of fetus was consistent with that of gestational age, and those with no complications in this and previous pregnancies were taken as normal pregnancy group. Plasma estradiol (E_3) levels were measured at 28, 32, 34, 36 and 38 weeks’ , HPL, uric acid and factor Ⅷ related antigen (ⅧRAg) / Ⅷ procoagulant activity (ⅧC), according to the mean of ± 2 standard deviations as the normal range; the other 21 cases of suspected clinical complications of fetal growth retardation Pregnant women from the diagnosis date until delivery to test the above indicators. Results Among the 21 suspected cases of pregnancy, the birth weight of 9 infants was lower than the 10th percentile, which was confirmed as Fetal growth retardation group with an average body weight of 2.08 kg. Twelve infants born above the 10th percentile of body weight In the unconfirmed group, the average body weight was 2.96 kg, but still significantly lower than that of the normal group (3.52 kg, p <0.001). The level of plasma E_3 in normal pregnancy increased slowly from 28 to 38 weeks of gestation, while the level of E_3 in delayed fetal growth was usually low. It was confirmed that there were 9 times in 35 times of observation, the E_3 value was lower than the normal one