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目的 探讨心脏瓣膜病变与系统性红斑狼疮 (SLE)病人的其他临床特征和某些并发症之间的联系。方法 10 4例SLE病人行超声心动图 (UCG)检查和有关狼疮的临床和实验室评价 ,UCG检查结果与 80名健康体检人员UCG检查结果进行对比。SLE病人和健康体检者随访约 4年。结果 SLE病人在初次和随访UCG中 ,瓣膜病变常见 ,发生率分别为 38%和 36 %。其中瓣膜增厚发生率最高 ,其次为瓣膜反流和赘生物。随访中瓣膜病变经常发生变化。瓣膜病变的存在与否与SLE病人的病程、狼疮活动、病情严重程度以及治疗方案无关。随访中有瓣膜病变的SLE病人的并发症(包括中风、外周栓塞、充血性心力衰竭、感染性心内膜炎和死亡 )发生率为 2 8% ,而无瓣膜病变者仅为 11%。结论 SLE病人瓣膜病变多见、易变 ,瓣膜病变的发生与病人的并发症发生率有关 ,而与病人的上述临床特征无关
Objective To investigate the association between valvular heart disease and other clinical features and some complications in patients with systemic lupus erythematosus (SLE). Methods A total of 104 patients with SLE underwent echocardiography (UCG) and clinical and laboratory evaluation of lupus. UCG test results were compared with UCG test results of 80 healthy people. SLE patients and health examination were followed up for about 4 years. Results SLE patients with primary and follow-up UCG had valvular lesions common, with rates of 38% and 36%, respectively. The highest incidence of valve thickening, followed by valvular regurgitation and vegetation. Valvular lesions often change during follow-up. The presence or absence of valvular disease is related to the course of SLE patients, lupus activity, severity of illness, and treatment regimen. Complications (including stroke, peripheral embolism, congestive heart failure, infective endocarditis, and death) were 28% of patients with valvular disease at follow-up, compared to 11% of patients without valvular disease. Conclusions SLE patients with valvular lesions more common, variable, valvular disease and the occurrence of the incidence of complications, but not with the patient’s clinical features