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目的探讨反复流产与染色体核型异常的关系。方法对女方有反复流产史的夫妇进行外周血淋巴细胞的染色体核型分析。结果268例夫妇中染色体核型异常者31例,其中,大Y有14例,常染色体多态性8例,平衡易位4例,倒位3例,插入1例,及47,XXY 1例。结论夫妻双方中有一方染色体异常,都可导致女方反复流产,反复流产的夫妇应进行染色体检查。
Objective To explore the relationship between recurrent abortion and chromosomal abnormalities. Methods Chromatin karyotype analysis of peripheral blood lymphocytes was performed on couples who had repeated abortion. Results There were 31 cases with abnormal chromosome karyotype in 268 couples. There were 14 cases with large Y, 8 cases with autosomal polymorphism, 4 cases with balanced translocation, 3 cases inverted, 1 case inserted, and 1 case with 47 and XXY . Conclusion One of the two sides of the couple chromosomal abnormalities, can lead to repeated abortion of the woman, repeated abortion couples should be chromosomal examination.