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目的:探讨肝硬化失代偿期门脉高压患者糖代谢异常的病因和机制。方法:选取40例肝硬化失代偿期门脉高压患者为肝病组,30例正常人为对照组,测定其空腹血糖、餐后2h血糖、糖化血红蛋白、空腹胰岛素、空腹C肽;比较2组检查结果的区别。结果:肝病组存在糖耐量异常,肝硬化Child分级比较,随病情加重,糖代谢紊乱加重。结论:肝硬化失代偿期门脉高压患者存在着糖代谢异常,可能是由于肝功能损害、胰岛素抵抗所致。
Objective: To investigate the etiology and mechanism of abnormal glucose metabolism in patients with decompensated cirrhosis and portal hypertension. Methods: Forty liver cirrhosis patients with decompensated portal hypertension were selected as the liver disease group and 30 normal controls as the control group. The fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, fasting insulin and fasting C-peptide were measured. The difference between the results. Results: There was impaired glucose tolerance in liver disease group, Child liver cirrhosis grading comparison, with the aggravation of disease, aggravating glucose metabolism disorders. Conclusion: Patients with cirrhosis and decompensated portal hypertension have abnormal glucose metabolism, which may be due to liver dysfunction and insulin resistance.