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新生儿缺氧缺血性脑病(HIE)主要是指围产期窒息导致的脑缺氧缺血性损伤。本文就HIE发病机理研究及诊疗进展作一综述。1 发病机理研究进展1.1 兴奋性谷氨酸大量增加:缺氧缺血时,脑内谷氨酸大量增加,过度激活谷氨酸受体,一方面造成Na+内流,Cl-和H2O亦被动进入引起细胞水肿,另一
Neonatal hypoxic-ischemic encephalopathy (HIE) mainly refers to cerebral hypoxic-ischemic injury caused by perinatal asphyxia. This article reviews the pathogenesis of HIE and the progress of diagnosis and treatment. 1 pathogenesis of 1.1 a significant increase in excitatory glutamate: Hypoxia-ischemia, a significant increase in the brain of glutamate, glutamate receptors over-activation, on the one hand caused by Na + influx, Cl- and H2O also passive into Cause cell edema, the other