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观察了中华眼镜蛇蛇毒（CCV）粗提品对大鼠补体溶血活性及豚鼠到大鼠异种心脏移植超急性排斥反应的影响。结果：一次性给予小剂量（0.25～0.5mg／kg）CCV腹腔注射后可明显降低大鼠血清补体溶血活性，4～24h后渐降至给药前1／2以下水平（均为P＜0．05），但均未能完全消除补体活性。CCV可明显延长异种移植心脏的存活时间达2．5～36h，对照组仅为25min；CCV与脾切除、前列腺素E1联用可进一步延长移植心的存活时间，最长1例达40h。病理结果提示，单核细胞可能参与延迟性异种移植排斥反应。证实补体系统在豚鼠对大鼠异种心脏移植超急性排斥反应中起主要介质作用。
The effects of the crude extract of Chinese cobra venom (CCV) on the hemolytic activity of complement in rats and the hyperacute rejection of guinea pig-to-rat xenograft heart transplantation were observed. RESULTS: After one-time administration of low-dose (0.25-0.5 mg/kg) CCV, the hemolytic activity of complement was significantly reduced in rats after 4 to 24 h, and then gradually decreased to 1/2 or less before administration (all P<0). .05) but failed to completely eliminate complement activity. CCV can significantly prolong the survival time of xenograft heart for 2.5 to 36 hours, and only 25 minutes for the control group. The combination of CCV and splenectomy and prostaglandin E1 can further prolong the survival time of the transplanted heart, and the longest one case reaches 40 hours. Pathological results suggest that monocytes may be involved in delayed xenograft rejection. It was confirmed that the complement system plays a major role in the hyperacute rejection of rat xenograft heart transplantation in guinea pigs.