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目的分析人苍白杆菌引起感染的临床特征、产AmpC酶与耐药性,为临床正确诊疗和合理应用抗生素提供科学依据。方法回顾性分析2012年1月-2016年7月本院细菌培养分离出人苍白杆菌患者的临床资料,头孢西丁三维试验法检测AmpC酶,K-B法进行药敏试验,采用WHONET 5.6软件进行耐药性分析。结果分离出的53株人苍白杆菌科室主要来自儿科和重症医学科,分别占39.7%和26.4%,标本类型主要为血液,占79.2%,该菌产AmpC酶率为92.5%,对青霉素类、β-内酰胺酶类抗生素高度耐药,但对喹诺酮类、碳青酶烯类、氨基糖苷类、复方磺胺类抗生素则高度敏感,耐药率均<5.0%。结论人苍白杆菌易引起免疫力低下患者感染,主要引起血流感染,该菌产AmpC酶率高,耐药率高,临床应对其进行耐药性监测,根据药敏试验结果合理选用抗生素。
Objective To analyze the clinical characteristics of the infection caused by Corynebacterium parvum and to provide AmpCase and drug resistance to provide a scientific basis for correct clinical diagnosis and rational use of antibiotics. Methods The clinical data of patients with Corynebacterium licheniformis isolated from our hospital from January 2012 to July 2016 were retrospectively analyzed. AmpC enzyme was detected by three-dimensional cefoxitin test, and susceptibility test was carried out by KB method. WHONET 5.6 software was used for resistance Pharmacological analysis. Results The 53 strains of Corynebacterium parvum isolated from our hospital mainly came from Pediatrics and Critical Care Medicine, accounting for 39.7% and 26.4% respectively. The specimens were mainly blood, accounting for 79.2%. The AmpC enzyme producing rate was 92.5% β-lactamase antibiotics are highly resistant, but quinolones, carbapenems, aminoglycosides, sulfamethoxazole are highly sensitive, resistance rates were <5.0%. Conclusion Corynebacterium parvum can easily cause infection in patients with low immunity, mainly causing bloodstream infection. The strain produced AmpC enzyme with high rate of drug resistance and clinical response to drug resistance. According to the result of drug susceptibility test, antibiotics should be selected reasonably.