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目的探讨新疆地区宫颈癌血清VEGF-C、D亚型水平与淋巴结转移及放疗后复发或淋巴结转移的相关性。方法纳入拟行根治性放化疗的宫颈鳞状细胞癌患者100例,采集血液标本,行根治性放化疗,并进行1年期随访,ELISA法检测血清VEGF-C、D亚型水平,分析治疗前VEGF-C、D与淋巴结转移的相关性,以及治疗后VEGF-C、D与复发或淋巴结转移的相关性。结果治疗前无淋巴结转移58例,一级淋巴结转移31例,二级淋巴结转移11例,血清VEGFC水平分别为(136.93±68.56)pg/ml,(147.77±76.43)pg/ml,(258.72±98.71)pg/ml,差异有统计学意义(F=12.45,P=0.001);血清VEGF-D分别为(2237.41±472.38)pg/ml,(2163.43±498.26)pg/ml,(2282.31±509.76)pg/ml,差异无统计学意义(F=0.339,P=0.71)。治疗后1年随访,患者全部存活,11例出现复发或淋巴结转移,余89例未出现复发或淋巴结转移,2组患者在治疗前血清VEGF-C分别为(251.33±121.39)pg/ml,(141.62±73.31)pg/ml,差异有统计学意义(t=3.24,P=0.001),在治疗后VEGF-C分别为(327.91±73.12)pg/ml,(153.31±49.38)pg/ml,差异有统计学意义(t=10.45,P<0.001);而VEGF-D在治疗前后均无统计学差异。结论血清VEGF-C水平与宫颈癌淋巴结转移明显相关,测定其血清含量有助于宫颈癌治疗前阳性淋巴结的辅助诊断,以及放疗后复发或淋巴结转移的判定。而VEGF-D水平与淋巴结转移无明确关系。
Objective To investigate the relationship between serum VEGF-C, D subtype and cervical lymph node metastasis and recurrence or lymph node metastasis in cervical cancer in Xinjiang. Methods 100 patients with squamous cell carcinoma of the cervix who underwent radical chemoradiotherapy were enrolled in this study. Blood samples were collected for radical radiotherapy and chemotherapy. The patients were followed up for 1 year. Serum levels of VEGF-C and D were detected by ELISA. Pre-VEGF-C, D and lymph node metastasis, and VEGF-C, D after treatment and relapse or lymph node metastasis. Results There were 58 cases without lymph node metastasis, 31 cases with primary lymph node metastasis and 11 cases with secondary lymph node metastasis before treatment. The serum levels of VEGFC were (136.93 ± 68.56) pg / ml, (147.77 ± 76.43) pg / ml and (258.72 ± 98.71 ) (pg / ml), the difference was statistically significant (F = 12.45, P = 0.001); the serum VEGF-D levels were 2237.41 ± 472.38 pg / ml, 2163.43 ± 498.26 pg / ml, 2282.31 ± 509.76 pg / ml, the difference was not statistically significant (F = 0.339, P = 0.71). One year after treatment, all the patients survived, and 11 cases had recurrence or lymph node metastasis. No recurrence or lymph node metastasis was found in the other 89 cases. Serum VEGF-C in the two groups before treatment were (251.33 ± 121.39) pg / ml, 141.62 ± 73.31) pg / ml, the difference was statistically significant (t = 3.24, P = 0.001). The VEGF-C after treatment was (327.91 ± 73.12) pg / ml and (153.31 ± 49.38) pg / There was statistical significance (t = 10.45, P <0.001). However, VEGF-D had no statistical difference before and after treatment. Conclusions The serum level of VEGF-C is significantly correlated with the lymph node metastasis of cervical cancer. The serum level of serum VEGF-C is helpful for the diagnosis of positive lymph nodes before treatment of cervical cancer and the relapse or lymph node metastasis after radiotherapy. There is no clear relationship between VEGF-D level and lymph node metastasis.